Table of Content

28 March 2021, Volume 10 Issue 1 Previous Issue    Next Issue

Commentary

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Clinical application of interventional robot system in percutaneous coronary intervention LI Chenguang, GE Junbo 2021, 10 (1):  1-3.  doi: 10.3969/j.issn.2095-378X.2021.01.001 Abstract ( 321 )   PDF (1151KB) ( 641 )   Save Coronary intervention has become a main treatment of coronary heart disease, but the traditional treatment is facing many shortcomings and challenges. This paper aims to explore the current situation and prospect of clinical application of interventional coronary heart surgery assisted by interventional robot system. The interventional robot system provides a more precise and standardized mode for interventional coronary surgery than manual operation, thereby effectively reduces the radiation exposure dose of doctors and patients and provides a safer option for infectious disease surgery. References | Related Articles | Metrics

Original article

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Expression of S100A7 in intrahepatic cholangiocarcinoma and its clinical significance LU Xiaoliang, WU Bin, CHEN Keji, LI Aijun, FAN Fei 2021, 10 (1):  4-8.  doi: 10.3969/j.issn.2095-378X.2021.01.002 Abstract ( 233 )   PDF (5941KB) ( 617 )   Save Objective To observe the expression of S100A7 in intrahepatic cholangiocarcinoma （ICC） and its clinical significance. Methods Tissue specimens from 30 cases of pathologically proven ICC were collected in the Eastern Hepatobiliary Surgery Hospital from January 2018 to January 2020. The expression of S100A7 in ICC tissue was analyzed by immunohistochemistry, Western blotting and PCR. Results The S100A7 level expressed in ICC tissue was significantly higher than that in para-carcinoma （50% vs. 10%, P<0.05）.The expression of S100A7 was correlated with the depth of tumor invasion, lymph node metastasis and TNM stage （all P<0.05）, but not correlated with the patient's sex, age, lymphatic invasion, tumor differentiation and distant metastasis. Conclusion S100A7 is overexpressesd in ICC, which is helpful to evaluate the prognosis of patients with ICC. References | Related Articles | Metrics

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Value of FRAX model in assessing fracture risk of Chinese elderly adults with type 2 diabetes XIE Zhuangli, YANG Jun, XUAN Miao, JI Peifang, LI Ying 2021, 10 (1):  9-13.  doi: 10.3969/j.issn.2095-378X.2021.01.003 Abstract ( 204 )   PDF (1229KB) ( 533 )   Save Objective To assess the fracture risk of elderly patients with and without type 2 diabetes mellitus （T2DM） by FRAX model, and to ascertain the validity of this model in assessing the fracture risk of elderly patients with T2DM in the mainland of China. Methods A total of 267 T2DM and 359 non-diabetic （control） patients were randomly selected, completed a questionnaire survey, underwent bone mineral density measurement, and were assessed by FRAX model. Binary regression analysis was used to evaluate the risk factors for high-risk fracture predicted by FRAX model. Results The body mass index （BMI）, waist-hip ratio, and the proportions of smoking and drinking were all higher in the T2DM group than those in the control group （P<0.001）. The bone mineral content, T value, and Z value of femoral neck （FN） and lumbar vertebra （L） in the T2DM group were also high. The T2DM group showed lower risks of 10-year major osteoporotic fracture （MOF） and hip fracture （HF） by FRAX-BMI model than the control group ［（4.27±2.84）% vs. （5.14±2.92）%, P<0.001, and （1.42±1.54）% vs. （1.83±2.23）%, P<0.001］. The T2DM group also showed a lower risk of MOF by FRAX-BMD model than the control group ［（5.28±4.41）% vs. （6.30±5.10）%, P<0.001］. Regression analysis results showed that the T score of FN, smoking, family history of hip fracture, and glucocorticoid use were associated with high-risk HF. The T score of FN, smoking, family history of HF, and history of brittle fracture were associated with high-risk MOF. T2DM was not associated with high-risk fracture predicted by the FRAX model. Conclusion The FRAX model predicts a lower 10-year fracture risk in elderly Chinese patients with T2DM than in non-diabetic patients, indicating that the model is not well suited for the Chinese population. References | Related Articles | Metrics

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Application of controlled low central vein pressure in complex laparoscopic hepatectomy HE Longguang, CHEN Qinshou, LI Dasheng, LI Fuliang, HUANG Junwei 2021, 10 (1):  14-16.  doi: 10.3969/j.issn.2095-378X.2021.01.004 Abstract ( 280 )   PDF (1266KB) ( 577 )   Save Objective To investigate the effect of controlled low central vein pressure on complex laparoscopic hepatectomy. Methods From January 2018 to May 2020, 60 patients with complex laparoscopic hepatectomy were randomly divided into an observation group （n=30） and a control group （n=30）. The observation group was treated by controlled low central venous pressure technique to maintain central venous pressure （CVP） at 1-3 cmH2O and SAP ≥ 90; while the control group was given conventional operation to keep CVP at 6-12 cmH2O. The intraoperative blood loss, operation time, blood gas indicators, liver and kidney functions, and bile leakage complications were compared between the two groups. Results The operation indexes in the observation group were better than those in the control group （P<0.05）. On postoperative day 1, the blood urea nitrogen, serum creatinine, alanine aminotransferase, and total bilirubin in both groups were increased, while the indexes in the observation group were slightly elevated （P<0.05）; there was no difference in pH and SpO2 between the two groups （P>0.05）, while the PaO2 and BE in the observation group were lower, and the HCO-3 was higher than those in the control group （P<0.05）. The incidence of bile leakage was lower in the observation group （P<0.05）. Conclusion In patients undergoing complex laparoscopic hepatectomy, the use of controlled low central venous pressure technique can reduce the amount of bleeding and blood transfusion and reduce the incidence of complications, thereby optimize operation effect, greatly improve the safety of liver surgery, and shorten the length of hospital stay, while not produce significant adverse effects on liver and kidney functions. References | Related Articles | Metrics

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Comparative analysis on effects of TAPP and open mesh plug and flat plate tension-free hernia repair on inguinal hernia LU Geng 2021, 10 (1):  17-18.  doi: 10.3969/j.issn.2095-378X.2021.01.005 Abstract ( 241 )   PDF (1249KB) ( 521 )   Save Objective To comparatively analyze transabdominal preperitioneal hernia （TAPP） repair and open mesh plug and flat plate tension-free hernia repair （Rutkow） on inguinal hernia. Methods A total of 100 patients with inguinal hernia were randomly divided into a control group and an observation group with 50 patients in each group. The control group received Rutkow surgery and the observation group received endoscopic TAPP surgery to compare the efficacy of the two groups. Results Complications including incision infection, recurrence, seroma, urinary retention, and testicular pain in the observation group were less than those in the control group （6% vs. 26%, P<0.05）. Conclusion TAPP repair for inguinal hernia produces less surgical complications, lower operational risks, and faster recovery, thus it is worthy of application. References | Related Articles | Metrics

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Clinical observation of laparoscopic herniorrhaphy in treatment of adult inguinal hernia DA Bo, XU Wenhai 2021, 10 (1):  19-21.  doi: 10.3969/j.issn.2095-378X.2021.01.006 Abstract ( 172 )   PDF (1251KB) ( 557 )   Save Objective To observe the clinical effect of laparoscopic inguinal herniorrhaphy （LIH） on adult inguinal hernia. Methods A total of 86 cases of adult inguinal hernia were randomly divided into an observation group （n=43） and a control group （n=43）. The observation group received LIH, and the control group received open tension-free herniorrhaphy （OTH）. The operative indexes, postoperative recovery, hernia recurrence, and incidence of complications of the two groups were compared. Results The operation time of the observation group was significantly longer than that of the control group （P<0.05）. The amount of intraoperative blood loss, the application rate of postoperative analgesics, the time of hospitalization, and the incidence of postoperative complications in the observation group were lower than those in the control group （P<0.05）. There was no significant difference in recurrence rate between the two groups at follow-up visits after 6-12 months. Conclusion LIH is effective in the treatment of adult inguinal hernia, with faster postoperational recovery, less pain, and less complications. References | Related Articles | Metrics

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Clinical application of tranexamic acid injection combined with absorbable gelatin sponge in lumbar spine surgery JI Xubiao, JIANG Xiaojun, YUN Chengming, LI Xiaolong 2021, 10 (1):  22-26.  doi: 10.3969/j.issn.2095-378X.2021.01.007 Abstract ( 219 )   PDF (1266KB) ( 567 )   Save Objective To explore the effects of local application of tranexamic acid injection combined with absorbable gelatin sponge during lumbar spine surgery on patient's postopereative hemorrhage, surgical outcome, and postoperative inflammation indicators. Methods Sixty patients undergoing lumbar spine surgery from July 2016 to July 2020 were randomly selected. The control group only used absorbable gelatin sponge, and the observation group additionally used tranexamic acid injection. The two groups were compared in first three 8 h drainage volumes, total drainage volume, extubation time, red blood cell volumes and Hb values at postoperative 1, 3, and 7 days, and postoperative inflammation indicators. Results The observation group showed significantly reduced first 8 h and total drainage volumes than the control group; there were significant differences between the first 8 h volume and the second or third 8 h volume in both groups; no difference was observed between the second and the third 8 h volume. The Hb and HCT at postoperative 1 d in the observation group were significantly higher than those in the control group （P<0.05）, and there were no significant differences before, 3 d after, and 7 d after operation （P>0.05）. Before treatment, there were no significant differences in serum inflammatory factors IL-6, IL-8, CRP, and TNF-α levels between the two groups, and were higher in the observation group than in the control group （P<0.05）; after 3 d of treatment, the serum inflammatory factor levels were higher than before （P<0.05）. Conclusion After combined treatment using tranexamic acid injection and absorbable gelatin sponge, the drainage volume is greatly reduced in the patients, showing a good hemostasis effect, and the inflammatory reactions are well controlled as well; therefore, the combination is worthy of clinical promotion. References | Related Articles | Metrics

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Clinical evaluation of intraocular pressure changes three years after implantation of implantable collamer lens with central hole （ICL V4C） ZHANG Xiaolin, YU Yanping 2021, 10 (1):  27-29.  doi: 10.3969/j.issn.2095-378X.2021.01.008 Abstract ( 299 )   PDF (1238KB) ( 670 )   Save Objective To observe the effect of implantation of implantable collamer lens with a central hole （ICL V4C） on intraocular pressure in patients with myopia. Methods Clinical data of 24 cases （48 eyes） from January 2016 to January 2017 were retrieved. All patients received ICL V4C implantation by the same operator. The patients were aged 21 to 45 years, average （32.8±6.5） years. The equivalent ball mirror was -4D~-18D, average （8.25±4.5） D. The astigmatism was between -0.5 D and -4 D, average （1.25±0.75） D. The intraocular pressure ranged between 10-21 mmHg with an average of （15.9±2.82） mmHg. The postoperative arch height was 150-750 μm. The patients were followed up for three years to observe the effect of ICL V4C implantation on intraocular pressure. Results The intraocular pressure values of patients at 1 week, 1 month, 3 months, 6 months, 1 year, 2 years, and 3 years after the operation were all within the range of 10-21 mmHg, which did not exceed threshold. The difference between the two eyes were all less than 5 mmHg and significantly lower than that of the control group （P<0.05）. Conclusion The intraocular pressures of myopic patients are all within a normal and safe range after ICL V4C implementation, and are not obviously changed three years after the surgery compared with before. References | Related Articles | Metrics

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Hemostatic effect of medical collagen sponge combined with batroxobin on wound after mixed hemorrhoids operation HE Li, XU Wenye 2021, 10 (1):  30-32.  doi: 10.3969/j.issn.2095-378X.2021.01.009 Abstract ( 226 )   PDF (1219KB) ( 569 )   Save Objective To observe and evaluate the efficacy and economic advantages of medical collagen sponge combined with batroxobin in the treatment of mixed hemorrhoids. Methods A total of 120 patients with grade Ⅲ and Ⅳ mixed hemorrhoids were randomly divided into three groups： experimental group, control group, and blank group, with 40 cases in each group. After external dissection and internal ligation, the experimental group was treated with medical collagen sponge combined with batroxobin for hemostasis, the control group with absorbable hemostatic membrane, and the blank group with ordinary gauze. The hemostatic effect, 24 h blood loss amount, postoperative infection, stool bleeding time, wound healing time, and patients' satisfaction were recorded and analyzed. Results The effective rates of the experimental group and the control group were both 100%, and that of the blank group was 75%. The 24 h blood loss amount, postoperative infection incidence, stool bleeding time, and wound healing time of the experimental group were lower than those of the control group and the blank group（P>0.05）, and the satisfaction score was significantly higher（P<0.01）. No postoperative infection occurred in the three groups. Conclusion Medical collagen sponge combined with batroxobin has a satisfying therapeutic effect and economic advantages, which is worthy of promotion. References | Related Articles | Metrics

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Tarsal canal approach and minimally invasive reduction with reverse retractor in treating calcaneal fracture ZENG Shiyuan 2021, 10 (1):  33-36.  doi: 10.3969/j.issn.2095-378X.2021.01.010 Abstract ( 239 )   PDF (1671KB) ( 603 )   Save Objective To investigate the effect of tarsal canal approach and minimally invasive reduction with reverse retractor on calcaneal fracture. Methods Fifty calcaneal fracture patients treated from February 2017 to February 2020 were selected. Tarsal canal approach and minimally invasive reduction with reverse retractor were performed; during surgery, small plate fixation was applied. The follow-up visit data, clinical indicators before and after surgery, as well as total effective rate, Bohler's angle recovery rate, and subtalar arthritis incidence rate among patients with different fracture types were compared. Results All of patients were followed-up after surgery, and the average follow-up time was （13.85±1.08） months. Among the 50 patients, 42 patients （84.00%） had a range of subtalar motion larger than 75.00%. After surgery, the calcaneal length and height were larger than before, the calcaneal width was lower, and the Gissane's angle and Bohler's angle were larger （P<0.05）. The total effective rates in type Ⅱ patients and type Ⅲ patients were 96.55% and 95.24%, respectively （P>0.05）. The Bohler's angle recovery rate in type Ⅲ patients was lower than that in type Ⅱ patients, and the incidence of subtalar arthritis was higher （P<0.05）. Conclusion The tarsal canal approach and minimally invasive reduction with reverse retractor are proven to be effective in treating calcaneal fracture. References | Related Articles | Metrics

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Analysis on diagnosis and treatment of 39 cases of acute gangrenous cholecystitis LIU Nanbin, XU Yan, WEI Yuhua, LIU Zhongyan, CHEN Quanning, SHI Baomin 2021, 10 (1):  37-41.  doi: 10.3969/j.issn.2095-378X.2021.01.011 Abstract ( 187 )   PDF (1209KB) ( 669 )   Save Objective To investigate the diagnosis of acute gangrenous cholecystitis and the effect of laparoscopy. Methods The clinical data of 39 cases of gangrenous cholecystitis treated from January 2017 to December 2019 were collected, and their diagnostic methods, surgical methods, and diagnosis and treatment results were analyzed. Results A total of 4365 cases of laparoscopic cholecystectomy （LC） were performed, of which 39 cases were diagnosed with gangrenous cholecystitis, accounting for 0.9% of total LC. Thirty-one of the 39 cases of gangrenous cholecystitis successfully underwent LC, 7 cases were converted to open cholecystectomy （OC） due to obscure anatomy at the triangle of the gallbladder, and 1 elderly patient with cardiopulmonary dysfunction underwent OC. Conclusion The diagnosis of gangrenous cholecystitis is difficult before operation. Ultrasound and upper abdominal CT examinations are effective methods to improve preoperative diagnosis rate. LC can safely treat most gangrenous cholecystitis, and in-time OC is suggested in case of severe adhesions and LC intolerance. References | Related Articles | Metrics

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Clinical comparison of low-temperature plasma radiofrequency operation and high-frequency electrosurgical resection in treatment of early tongue cancer YAN Guoxin, REN Hang 2021, 10 (1):  42-44.  doi: 10.3969/j.issn.2095-378X.2021.01.012 Abstract ( 179 )   PDF (1226KB) ( 515 )   Save Objective To compare between low-temperature plasma radiofrequency surgery and high-frequency electrosurgical resection in the treatment of early tongue cancer. Methods Forty-eight patients with early tongue cancer treated from January 2010 to January 2015 were selected as study subjects and divided into a control group （n=24） and an observation group （n=24） by a double-blind method. The control group was treated by high-frequency electrosurgical resection, and the observation group was treated by low-temperature plasma radiofrequency surgery. The intraoperative blood loss amount, the degree of pain at different time points after operation ［Visual Analogue Scale （VAS）］, the rate of wound bleeding 6 months after operation, and the recurrence rate 5 months after operation were compared between the two groups. Results The intraoperative blood loss amount of the observation group was significantly less than that of the control group （P<0.05）; the VAS scores of the observation group were significantly lower than those of the control group 1, 3, and 5 d after surgery （P<0.05）; the differences in postoperative wound bleeding rate and recurrence rate between the two groups were not significant （P>0.05）. Conclusion Low-temperature plasma radiofrequency surgery for early tongue cancer patients can reduce intraoperative blood loss amount and relieve postoperative pain. References | Related Articles | Metrics

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Anesthesia management and prevention and control practices of emergency cesarean section during COVID-19 epidemic YUAN Bo, WANG Yan, ZOU Weiwei 2021, 10 (1):  45-48.  doi: 10.3969/j.issn.2095-378X.2021.01.013 Abstract ( 169 )   PDF (1244KB) ( 655 )   Save Objective To study the anesthesia management and prevention and control practices of emergency cesarean section during the COVID-19 epidemic. Methods A total of 20 pregnant women who were required to undergo cesarean section in our hospital were selected from January 2020 to July 2020. Surgical anesthesia management and prevention and control measures were adopted. The physical conditions and emotional scores of pregnant women before and after the implementation were observed and compared. Results Compared with before, the general health status and physiological function scores of the pregnant women were significanlty reduced after the prevention and control （P<0.05）; the SAS and SDS scores were also reduced after the implementation （P<0.05）. Conclusion During the epidemic, adopting surgical anesthesia management and prevention and control measures for pregnant women undergoing emergency cesarean section can restore their physical functions and improve their mood. References | Related Articles | Metrics

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Comparative analysis of laparoscopic recanalization and simple recanalization for recanalization after tubal sterilization FU Yiyuan, HUANG Zheng, WANG Yibin, HUANG Jiezhen, LI Qiufen 2021, 10 (1):  49-51.  doi: 10.3969/j.issn.2095-378X.2021.01.014 Abstract ( 158 )   PDF (1262KB) ( 649 )   Save Objective To compare the therapeutic effects of laparoscopic recanalization and simple recanalization on recanalization after tubal sterilization. Methods The clinical data of 62 patients who underwent recanalization surgery after tubal sterilization from January 2017 to June 2020 were retrieved for a retrospective analysis. According to the surgical methods, 31 patients who received simple recanalization were included in the control group, and the other 31 patients who underwent laparoscopic recanalization were included in the study group. Recanalization, clinical indicators, and postoperative pregnancy were observed of the two groups. Results The recanalization rate of the study group （96.77%） was higher than that in the control group （74.19%）, and the bilateral obstruction rate of the study group was lower than that of the control group （P<0.05）. The study group's first postoperative exhaust recovery time and operation time were longer than the control group's, and hospital stay was shorter and intraoperative blood loss was less （P<0.05）. The intrauterine pregnancy rate in the study group was higher than that in the control group, and the missed abortion and infertility rates were lower （P<0.05）. There was no significant difference in the ectopic pregnancy rate between the two groups （P>0.05）. Conclusion Laparoscopic recanalization performed in patients undergoing tubal sterilization can result in longer operation time, but less intraoperative blood loss and higher recanalization rate and postoperative intrauterine pregnancy rate than simple recanalization. References | Related Articles | Metrics

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Effect of dexmedetomidine and dezocine in patient-controlled intravenous analgesia on postoperative sleep quality and cognition of elderly patients LU Feifei, FENG Xiumei, CAO Yong, LI Yanmin, CHENG Wei 2021, 10 (1):  52-56.  doi: 10.3969/j.issn.2095-378X.2021.01.015 Abstract ( 181 )   PDF (1284KB) ( 579 )   Save Objective To investigate the effect of dexmedetomidine （Dex） combined with dezocine in patient-controlled intravenous analgesia （PCIA） on the quality of sleep and the early cognitive function of elderly patients with spinal anesthesia after operation. Methods Sixty-five elderly patients aged 80-96 years undergoing spinal anesthesia from the department of orthopedics were randomly divided into two groups by random table method： dezocine group （group C, n=32） and dezocine plus Dex group （group D, n=33）. Pittsburgh sleep quality index （PSQI） was assessed at preoperation, 24 h and 48 h postoperation, and before discharge, respectively. Visual Analogue Scale （VAS） score and Ramsay score were observed 4, 8, 12, 24, and 48 h after surgery, respectively. Mini-Mental Status Examination （MMSE） score was recorded at 1d before surgery and 1, 3, 7 d after surgery, respectively, and the incidence rate of postoperative cognitive dysfunction was evaluated as well. The postoperative incidence rates of nausea, vomiting, somnolence, and urinary catheter discomfort were also evaluated. Results The PSQIs in the group D at postoperative 24 h and 48 h and before discharge were significantly lower than those in the group C （P<0.05）. The postoperative Ramsay score in the group D was significantly higher than that in the group C （P<0.05）. The postoperative MMSE scores in the group D were also significantly higher （P<0.05）, and the incidence rate of POPD was lower （P<0.05）. The group D showed a lower VAS score, and less nausea, vomiting, urinary catheter discomfort incidence rates （P<0.05）. Conclusion Dex combined with dezocine in PCIA help improve the quality of sleep and reduce postoperative cognitive dysfunction in elderly patients. References | Related Articles | Metrics

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Effects of different anesthesia methods on postoperative outcome of patients undergoing laparoscopic radical resection of colorectal cancer WANG Xiaona, LIN Xulin, LIN Gengbin, HUANG Junping 2021, 10 (1):  57-60.  doi: 10.3969/j.issn.2095-378X.2021.01.016 Abstract ( 185 )   PDF (1261KB) ( 574 )   Save Objective To analyze the effects of different anesthesia methods on postoperative outcome of patients with laparoscopic radical resection of colorectal cancer. Methods A retrospective analysis was performed on 90 patients undergoing laparoscopic radical resection of colorectal cancer admitted from January 2019 to June 2020. Among them, 30 patients admitted from January 2019 to June 2019 were selected as intravenous analgesia group and given general anesthesia combined with intravenous analgesia; 30 patients admitted from July 2019 to December 2019 as epidural analgesia group and given general anesthesia combined with epidural analgesia; and 30 patients admitted from January 2020 to June 2020 as transversus abdominis plane block group and given general anesthesia combined with transversus abdominis plane block. The time of spontaneous breathing recovery, eye opening, tracheal removal, and gastrointestinal tract recovery, and the pain degree of the three groups were compared. Results After the operation, the spontaneous breathing recovery time, eye opening time, tracheal removal time, and gastrointestinal recovery time of the epidural analgesia group and the transversus abdominis plane block group were shorter than those of the intravenous analgesia group （P<0.05）. At postoperative 4 h, 6 h, and 12 h, the VAS scores of the epidural analgesia group and the transversus abdominis plane block group were lower than those of the intravenous analgesia group （P<0.05）. Conclusion General anesthesia combined with epidural analgesia or transversus abdominis plane block is beneficial to the postoperative outcome of patients undergoing laparoscopic radical resection of colorectal cancer, and reduce pain as well. References | Related Articles | Metrics

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Effect of dexmedetomidine combined with ropivacaine femoral nerve block on analgesia after total hip replacement CHEN Jing, WU Suiping, CAI Yiliang, CHEN Jiachen, XIE Kuishan 2021, 10 (1):  61-63.  doi: 10.3969/j.issn.2095-378X.2021.01.017 Abstract ( 173 )   PDF (1256KB) ( 578 )   Save Objective To investigate the effect of dexmedetomidine combined with ropivacaine femoral nerve block on postoperative analgesia after total hip replacement （THR）. Methods A total of 160 patients with THR admitted from September 2018 to September 2020 were selected as study subjects. The patients were divided into a control group （odd number, 80 cases） and an observation group （even number, 80 cases） by digital odd-even method. Both groups received continuous femoral nerve block for analgesia after surgery, with a background dose of 8 mL/h and a shock dose of 4 mL per 30 min. The control group was prescribed 0.2% ropivacaine and the observation group was prescribed 1 μg/mL dexmedetomidine combined with 0.1% ropivacaine. The morphine consumption, Visual Analogue Scale （VAS） score at postoperative 6 h, 12 h, and 24 h, Pittsburgh Sleep Quality Index （PSQI） at postoperative 1 d and 7 d, and adverse reactions were compared between the two groups. Results The morphine consumption, the VAS scores 6 h and 12 h after operation, the PSQIs 1 d and 7 d after operation, and the incidence of complications of the observation group were significantly lower than those of the control group （P<0.05）. Conclusion Dexmedetomidine combined with ropivacaine femoral nerve block has a significant analgesic effect after THR operation, and it can reduce morphine dosage and postoperative pain, improve sleep quality, and reduce postoperative complications. References | Related Articles | Metrics

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Research progress on anti-lymphangiogenesis in colorectal cancer WANG Hui, WANG Fangtao, FAN Yuezu 2021, 10 (1):  64-67.  doi: 10.3969/j.issn.2095-378X.2021.01.018 Abstract ( 214 )   PDF (1307KB) ( 577 )   Save Tumor lymphangiogenesis is a complex process of tumor lymphatic endothelial cell proliferation, migration, and lymphangiogenesis. It is regulated by various signaling pathways, lymphangiogenic factors, and their receptors, which plays an important role in tumor lymphatic metastasis, and is related to the poor prognosis of patients. With the in-depth study of lymphangiogenesis and its endothelial markers, the molecular mechanism of lymphatic metastasis in colorectal cancer has been better understood, and new anti-tumor lymphangiogenesis treatments have been developed. The present paper reviewed studies of tumor lymphangiogenesis and its molecular regulation mechanisms, colorectal cancer lymphatic metastasis, and anti-lymphangiogenesis in colorectal cancer. References | Related Articles | Metrics

Medical instrument column

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Progress on electrosurgical equipments LI Jiaxuan, LI Liangbo, LIU Hui, QIAN Kun, LIU Bin 2021, 10 (1):  68-69.  doi: 10.3969/j.issn.2095-378X.2021.01.019 Abstract ( 413 )   PDF (1077KB) ( 1068 )   Save Electrosurgery enquipments include high-frequency electric knife, argon plasma coagulation, and bipolar vessel-sealing devices. This article introduced the principles and advances of electrosurgery equipments for better understanding and proper use. References | Related Articles | Metrics

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Standardized management of medical device users XU Yiyi 2021, 10 (1):  70-73.  doi: 10.3969/j.issn.2095-378X.2021.01.020 Abstract ( 167 )   PDF (1155KB) ( 496 )   Save Objective In hospitals, users should follow relevant codes to apply, use, preserve, maintain, and dispose medical devices. However, that has not always been the case.Medical equipment departments are expected to better understand medical device users, optimize user guidance, and help users to treat medical devices. Methods A questionnaire survey was conducted and a total of 145 questionnaires were returned and analyzed. Results The results of questionnaire survey showed that the users' behaviors towards medical devices were not as rational as expected in the absence of strict rules. Conclusions Based on these results and Kohlberg's Stages of Moral Development, it can be concluded that appropriate guidance will improve user's behavior patterns when using medical devices. References | Related Articles | Metrics

Nursing

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Review on nursing strategies to prevent lower limb venous thrombosis in neurosurgical patients WEI Baozhen 2021, 10 (1):  74-77.  doi: 10.3969/j.issn.2095-378X.2021.01.021 Abstract ( 285 )   PDF (1162KB) ( 665 )   Save Venous thrombosis of lower extremities mainly refers to the abnormal coagulation of the blood in the deep venous cavity of patients, which leads to the obstruction of the venous lumen and further venous reflux disorder. It is a common complication in neurosurgical patients, with unilateral extremity swelling and local pain as the major symptoms, which seriously affect recovery. If interventions are not implemented in time, it will be complicated with other diseases, or even endanger life. Therefore, to reduce venous thrombosis of the lower limbs, it is especially necessary for neurosurgical patients to take effective preventive measures. This paper analyzed and reviewed the pathogenesis and causes of venous thrombosis of lower extremities, as well as preventive nursing measures and effects, aiming to provide evidence for nursing care for neurosurgical patients. References | Related Articles | Metrics

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Effect of cold therapy on limb pain and swelling after total knee arthroplasty LI Yanqing 2021, 10 (1):  78-80.  doi: 10.3969/j.issn.2095-378X.2021.01.022 Abstract ( 185 )   PDF (1230KB) ( 756 )   Save Objective To evaluate the effect of cold therapy on limb pain and swelling after total knee arthroplasty （TKA）. Methods From January 2019 to January 2020, 110 patients with postoperative pain and swelling after TKA were randomly assigned to a control group and a study group, with 55 cases in each group. The control group was given routine therapy and nursing; on the basis of the former, the study group was given intermitted treatment with iced therapeutic pad for 72 h. Improvements in limb pain and swelling conditions were observed. Results After 6 h, 24 h, 48 h, and 72 h of designed intervention, the Visual Analogue Scale （VAS） scores of the study group were significantly lower than those of the control group （P<0.05）; after 72 h, the circumferences above 10 cm and below 10 cm of kneecap of the two groups were significantly smaller than before, and the difference of the study group was larger than that of the control group （P<0.05）. Conclusion Cold therapy can effectively relieve limb pain and swelling of TKA patients. In addition, nursing interventions can further enhance the surgical effects of TKA. References | Related Articles | Metrics