宫颈浸润性复层产黏液性癌3例临床病理分析并文献复习

doi:10.3969/j.issn.2095-378X.2024.01.009

外科研究与新技术（中英文） ›› 2024, Vol. 13 ›› Issue (1): 39-43.doi: 10.3969/j.issn.2095-378X.2024.01.009

宫颈浸润性复层产黏液性癌3例临床病理分析并文献复习

陈雪, 曾郁, 毕小涵, 张素霞

同济大学附属同济医院病理科, 上海 200065

收稿日期:2023-07-17 出版日期:2024-03-28 发布日期:2024-04-12
通讯作者: 张素霞,电子信箱：zhangsuxia2006@163.com
基金资助:
上海市科学技术委员会科研项目（21Y11908800）

Invasive stratified mucin-producing carcinoma： Clinicopathological analysis of three cases and literature review

CHEN Xue, ZENG Yu, BI Xiaohan, ZHANG Suxia

Department of Pathology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China

Received:2023-07-17 Online:2024-03-28 Published:2024-04-12

摘要/Abstract

摘要： 目的对一种新命名的人乳头瘤病毒（HPV）相关的宫颈黏液腺癌——宫颈浸润性复层产黏液性癌（ISMC）进行病例分析,为这种罕见疾病提供更多临床和病理数据。方法回顾性分析3例ISMC,并结合相关文献对其病理学特征、免疫表型、HPV基因分型及预后进行探讨。结果 ISMC肿瘤细胞表现为结构模式和细胞形态的多样性。肿瘤细胞胞质内含多少不等的黏液,瘤巢内外均可见中性粒细胞浸润。3例均发现凋亡小体和有丝分裂。免疫组织化学染色显示p16和CK7呈弥漫强（+）,PAX8、p40和CK5/6巢周少量（+）。结论 ISMC是一种少见、具有广泛形态学谱的HPV相关腺癌。PAX8、CK5/6和p40独特的表达模式使其可以作为ISMC诊断的有效标志物。ISMC预后较差,即便检测到少量ISMC成分也应在诊断中注明其占比,此点尤为重要。

关键词: 浸润性复层产黏液性癌, 组织学特征, 免疫组织化学

Abstract: Objective To conduct a case study on invasive stratified mucin-producing carcinoma （ISMC）, a newly named human papillomavirus （HPV）-related cervical mucinous adenocarcinoma, and provide clinical and pathological data for this rare disease. Methods Three cases of ISMC were retrospectively analyzed, and the pathological characteristics, immunophenotype, HPV genotyping, and prognosis were explored in combination with relevant literature. Results ISMC tumor cells exhibited a diversity of structural patterns and cell morphology. The cytoplasm of the tumor cells contained different amounts of mucus, and neutrophil infiltration could be seen around the nests and intratumorally. Apoptotic bodies and mitosis were found in all three cases. Immunohistochemistry showed p16 and CK7 were diffuse and strong （+）, while PAX8, p40, and CK5/6 were slight （+） around the nests . Conclusion ISMC is a rare, HPV-associated adenocarcinoma with a broad morphological spectrum. The unique expression patterns of PAX8, CK5/6, and p40 can be used as effective markers for ISMC diagnosis. ISMC has a poor prognosis, and it is important that even if a small amount of ISMC components are detected, their percentages should be noted in the diagnosis.

Key words: Invasive stratified mucin-producing carcinoma, Histological feature, Immunohistochemistry

中图分类号:

R602

陈雪, 曾郁, 毕小涵, 张素霞. 宫颈浸润性复层产黏液性癌3例临床病理分析并文献复习[J]. 外科研究与新技术（中英文）, 2024, 13(1): 39-43.

CHEN Xue, ZENG Yu, BI Xiaohan, ZHANG Suxia. Invasive stratified mucin-producing carcinoma： Clinicopathological analysis of three cases and literature review[J]. Surgical Research and New Technique, 2024, 13(1): 39-43.

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宫颈浸润性复层产黏液性癌3例临床病理分析并文献复习

Invasive stratified mucin-producing carcinoma： Clinicopathological analysis of three cases and literature review

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